McGill University

McGill University

Postdoctoral Researcher

Job ID: JR0000058361

Cestari Lab (https://www.cestarilab.com)

Overview

A postdoctoral position is available to investigate signalling, transcriptional control, and genome organization in trypanosomes. Trypanosomes are single-celled protozoan parasites that cause diseases in humans and animals. The candidate will explore the role of signalling and transcriptional regulators in genome organization and the expression of genes essential for pathogen evasion of host antibody responses. This pathogen periodically alters the expression of genes encoding surface antigens to escape antibody recognition during infection, a process known as antigenic variation.

The project includes genome 3D organization (Hi-C), generation of mutant cell lines, DNA/RNA sequencing, ChIP-seq, protein interaction analysis (mass spectrometry), and single-cell sequencing. Knowledge of molecular and cellular biology and computational approaches is desirable.

References: Touray et al. 2023 eLife (https://elifesciences.org/articles/89331, https://bio-), Touray et al. 2023 Bio-protocol (protocol.org/en/bpdetail?id=4904&type=0), Cestari and Stuart 2015 PNAS (https://www.pnas.org/doi/full/10.1073/pnas.1501206112).

Duties

Perform experiments to generate mutant cells and analyze DNA, RNA, and protein changes. Large data analysis using sophisticated computational resources/tools. Write publications, attend conferences, organize data, and support less experienced trainees. Conduct independent research and collaborate with team members.

Skills

PhD in molecular and cellular biology or related field. Hands-on molecular and cellular biology experience and knowledge of bioinformatics.

Additional information

Group C (Unionized) Postdoctoral Researchers are Research Fellows recognized by the Quebec government employed at McGill with a valid Doctoral degree (PhD or MD) for a maximum of 5 years after obtaining their Doctoral Degree.

The incumbent is unionized if more than 25% of his salary is paid by McGill Research funds.

Group C Unionized hold a dual status as both students and McGill employees and are members of the AMURE (Postdocs) bargaining unit. Their pay, benefits, working conditions, etc. are governed by their collective agreement.

Job Types: Full-time, Fixed term contract

Contract length: 12 months

Pay: From $45,000.00 per year

Work Location: In person