Postdoctoral Fellow in Molecular Genetics of Human diseases

Postdoctoral Fellow in Molecular Genetics of Human diseases

Mayo Clinic

A post-doctoral fellow position is available in the laboratory of Dr. Xiaolei Xu, Professor of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine.  The successful applicant will join a team that is leveraging powerful zebrafish genetics to model human cardiovascular diseases, to decipher underlying mechanisms, and to develop new therapies.  The lab recently integrated African Turquois Killifish as a new animal model for studying normative cardiac and kidney aging. Below please find two representative manuscripts from the lab on doxorubicin-induced cardiotoxicity.  Applications are invited from candidates who have a strong background in molecular biology, genetics and/or cardiovascular diseases. Previous experience in animal models of human diseases and/or bioinformatics are favored, but not required. Qualified candidates must be self-motivated and have a strong commitment to basic research.  

Ma X, Zhu P, Ding Y, Zhang H, Qiu Q, Dvornikov AV, Kim M, Wang Y, Lowerison M, Herrmann J, Ekker S, Hsiai TK, Lin X and Xu X. (2020)  Retinoid X receptor alpha is a spatiotemporally-specific therapeutic target for doxorubicin-induced cardiomyopathy in adult zebrafish. Science Advances 6(5), eaay2939, PMID: 32064346.

Wang Y, Lu X, Wang X, Qiu Q, Zhu P, Ma L, Ma X, Herrmann J, Lin X, Wang W, Xu X. (2021) atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity. Circ Res. Aug 13. PMID: 34384247.

Mayo Clinic College of Medicine is a not-for-profit organization that integrates research with clinical practices and education in multi-campus environment. Mayo offers an attractive benefit package. Salary will be commensurate with the candidate's experience.

Applications, including curriculum vitae and bibliography, summary of past accomplishments, and the names of three references, should be sent to:

Xiaolei Xu, PhD.

Mayo Clinic

Stabile 4-10

200 First Street SW

Rochester, MN USA 55905

Email: xu.xiaolei@mayo.edu

Phone number: 507-284-0685

Further enquires (enclosing a CV) regarding the scope and detail of the project should be addressed to: xu.xiaolei@mayo.edu or visit https://www.mayo.edu/research/labs/zebrafish-genetics